Protocol First Joins Flatiron Health

December 17, 2021
Combination helps bridge the gap between real-world care and clinical research 


Protocol First, a software solutions provider focused on accelerating clinical research, has joined Flatiron Health as a wholly owned subsidiary, the two companies announced today.

“This is a win-win for both companies,” said Carolyn Starrett, Flatiron CEO. “Flatiron and Protocol First share a common vision in which technology and software increasingly bridge the gap between real-world care and clinical research.”

Protocol First’s technology enhances research efficiency by breaking down silos between sites, study sponsors and contract research organizations (CROs.) Effective Dec. 14, Protocol First’s employees and operations joined Flatiron’s Clinical Research business unit, which builds on Flatiron’s established leadership in real-world evidence with new technologies that better integrate research into everyday clinical care.

“Flatiron has deep expertise in unstructured-data processing, experience building software that integrates seamlessly into site workflows, and an engaged network of community and academic research sites,” said Alex Deyle, General Manager, Clinical Research at Flatiron. “Protocol First’s technology expands and accelerates our ability to drive much-needed innovation in clinical research.”

Protocol First aims to reduce the operational complexity of data collection and validation in clinical research by leveraging proven technologies and standards. The team, led by CEO Hugh Levaux and CTO Amit Shah, has developed several industry-defining software solutions that have been adopted by many leading CROs and biopharma companies. The technology is designed to handle the unique complexities of research in oncology as well as other disease areas. Plans are being developed to integrate the direct EHR-to-EDC connector application Clinical Pipe – already in use with major academic medical centers and health systems – with Flatiron’s OncoEMR, which is used by hundreds of community cancer centers across the U.S.

“We are very excited about this combination, which will take our technology to the next level, scaling and broadening its availability across the life sciences industry,” said Levaux, who joins Flatiron as Vice President, Clinical Research. “The transition will be seamless for our customers, and the future belongs to the patients we will all serve with even better solutions.”

About Protocol First

Protocol First, Inc., founded in 2015 and headquartered in Salt Lake City, UT, develops next-generation technology solutions for complex clinical trials in the Life Sciences industry. In addition to its flagship Protocol First suite of cloud-based solutions (eProtocol, Source Upload and EDC), Protocol First has launched Clinical Pipe, the industry’s first connector app that offers system-agnostic EHR-to-EDC interoperability. The application supports major EHR and EDC systems including Epic, Cerner, and Athena, as well as Medidata Rave and its own P1 platform. For additional information visit


About Flatiron
Flatiron Health is a healthtech company expanding the possibilities for point of care solutions in oncology and using data for good to power smarter care for every person with cancer. Through machine learning and AI, real-world evidence, and breakthroughs in clinical trials, we continue to transform patients’ real-life experiences into knowledge and create a more modern, connected oncology ecosystem. Flatiron Health is an independent affiliate of the Roche Group. @FlatironHealth

Media Contact: Nina Toor