Prognostic value of translocation 11;14 in patients with relapsed/refractory myeloma receiving anti-CD38 therapy

December 16, 2022

Our summary

Antibodies that target CD38 have transformed the treatment landscape for patients with multiple myeloma (MM). The translocation t(11;14) is present in ~15% of patients newly diagnosed with MM and, despite still being classified as standard risk MM, is associated with a unique clinical and pathological phenotype. Prior work using large datasets has demonstrated that the prognosis for patients t(11;14) may be slightly worse than standard risk disease when patients are treated with novel agents.

In this study, researchers used clinical and cytogenetic data from a large group of real-world patients with MM to compare outcomes of patients receiving anti-CD38 therapy with and without t(11;14).

Why this matters

Patients with t(11;14) represent a small fraction of patients with MM enrolled in randomized trials. Therefore there is little data on the impact of t(11;14) on the prognosis of other patient cohorts receiving anti-CD38 therapies.

As a result, clinical trials may not adequately evaluate the impact of novel therapies on rare cytogenetic subsets, and the use of real-world data presents a significant opportunity to answer this.

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