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The association between baseline hepatic or renal function and clinical outcomes for patients with NSCLC treated with a PD-1/PD-L1 blocking antibody using real-world and trials data

Clinical Pharmacology & Therapeutics

Liu Q, Mathur R, Xu Y, Torres AZ, Miksad RA, Liu C, Smithson H, Wang Y, Hao Zhu, Booth B, Huang S, Zhi J, Sridhara R, Blumenthal GM, Larkins E, Mishra-Kalyani PS, Rivera DR, Kluetz PG, Sharon E

Publication summary

Approach to machine learning for extraction of real-world data variables from electronic health records

Adamson BJ, Waskom M, Blarre A, Kelly J, Krismer K, Nemeth S, Gippetti J, Ritten J, Harrison K, Ho G, Linzmayer R, Bansal T, Wilkinson S, Amster G, Estola E, Benedum B, Fidyk E, Estevez M, Shapiro W, Cohen AB.

Beyond synthetic controls: Near-term opportunities for regulatory RWE