Real-world evidence at ASCO21: Explore new research here

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An automated EHR-based tool to improve patient identification for biomarker-driven trials

Lakhanpal, S, Hawkins, K, Dunder, Steven, Donahue, K, Richey, MM, Liu, E, Brachfeld, A, Shelley, A, Sutton, LM, Green, D, Siu, E, Hamrick, HJ

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

Clinical characteristics, treatment patterns, and overall survival of real-world patients with idiopathic multicentric Castleman disease

Cohen, AB, Swaminathan, A, Wang, X, Zamora, S, Repucci, MA, Kelly, J, Hannan, M, Sepler, D, Sridharma, S, Orlando, A, Leybovich, B, Fajgenbaum, D

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

Time to treatment initiation for patients with advanced cancer documented during the COVID-19 pandemic

Takvorian, SU, Parikh, RB, Vader, D, Wileyto, EP, Clark, AS, Lee, DJ, Goyal, G, Rocque, GB, Dotan, E, Geynisman, DM, Phull, P, Spiess, PE, Kim, RY, Davidoff, AJ, Gross, CP, Miksad, RA, Calip, GS, Shulman, L, Mamtani, R, Hubbard, RA

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

ERBB2 copy number (CN) as a quantitative biomarker for real-world (RW) outcomes to anti-HER2 therapy in advanced gastroesophageal adenocarcinoma (adv GEA)

Klempner SJ, Zhang, L, Graf, RP, Madison, RW, Snider, JW, Cho-Phan, C, Castellanos, EH, Li, G, Nimeiri, H, Oxnard, G, Venstrom, JM, MGregor, K, Schrock, AB

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

Analysis of real world data (RWD) for metastatic breast cancer (mBC) patients (pts) without germline BRCA (gBRCA) alterations treated with PARP inhibitors (PARPi)

Tung, N, Madison, RW, Pavlick, D, Sokol, ES, Snow, T, Sondhi, A, Frampton, GM, Venstrom, JM, Castellanos, EH, Schrock, AB, MGregor, K

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

May 2021

Manuscript

Health Services Research

Flatiron-authored

Real-world treatment patterns and outcomes of abemaciclib for the treatment of HR+, HER2-metastatic breast cancer

Carter, GC, Sheffield, KM, Gossai, A, Huang, Y, Zhu, YE, Bowman, L, Smyth, EN, Mathur, R, Cohen, AB, Rasmussen, E, Balakrishna, S, Guimaraes, CM, Rybowski, S, Seidman, AD

May 2021

Manuscript

Current Medical Research and Opinion

Flatiron-authored

Patient with lobular carcinoma of the breast and activating AKT1 E17K variant

Trivedi, H, Hamdani, O, Thomas, B, Richard, J, Shah, K, Raskina, K, Zhang, L, Madigan, A, Fox, M, Wander, S, Frigault, M, Alexander, BM, Srkalovic, G

April 2021

Manuscript

Acta Medica Academia

April 2021

Manuscript

Scientific Reports

TRK fusion cancer: patient characteristics and survival analysis in the real-world setting

Bazhenova, L, Lokker, A, Snider, JW, Castellanos, EH, Fisher, V, Fellous, M, Nanda, S, Zong, J, Keating, K, Jiao, X

April 2021

Manuscript

Targeted Oncology

Flatiron-authored

Artificial intelligence for prognostic scores in oncology: a benchmarking study

Loureiro, H, Becker, T, Bauer-Mehren, A, Ahmidi, N, Weberpals, J

April 2021

Manuscript

Frontiers in Artificial Intelligence

April 2021

Manuscript

JAMA Oncology

Treatment patterns in patients with metastatic non-small-cell lung cancer in the era of immunotherapy

Stenehjem, D, Lubinga, S, Betts, KA, Tang, W, Jenkins, M, Yuan, Y, Hartman, J, Rao, S, Lam, J, Waterhouse, D

April 2021

Manuscript

Future Oncology

April 2021

Abstract

AACR Annual Meeting

April 2021

Abstract

AACR Annual Meeting

Immune checkpoint inhibitor therapy for metastatic colorectal cancer: real-world practice patterns and predictors of overall survival

Bari, S, Matejcic, M, Kim, R, Xie, H, Carballido, E, Sahin, I, Powers, B, Felder, S, Schmit, SL

April 2021

Abstract

AACR Annual Meeting

April 2021

Abstract

AACR Annual Meeting

Changes over time in real-world next-generation sequencing test use in patients with advanced non-small cell lung cancer

Swaminathan, A, Stergiopoulos, S, Snider, JW, Fisher, V, Castellanos, EH, Snow, T, Cho-Phan, C, Comment, L, Cunningham, R, McCusker, M

April 2021

Abstract

AACR Annual Meeting

Flatiron-authored

Comprehensive genomic profiling in breast cancer: patterns and results from a clinico-genomic database

Rody, A, Chaudhary, N, Craggs, C, Debiasi, M, Erb, G, Fisher, V, McCusker, M, Snow, T, Losada, MV, Luhn, P

April 2021

Abstract

AACR Annual Meeting

Flatiron-authored

Evaluating oncology trial eligibility criteria using real-world data and AI

Liu, R, Rizzo, S, Whipple, S, Pal, N, Pineda, AL, Lu, MW, Arnieri, B, Lu, Y, Capra, WB, Copping, R, Zou, J

April 2021

Manuscript

Nature

Adherence to NCCN ALK testing guidelines for patients with advanced non‐small cell lung cancer in US community medical centers

Bernicker, E, Xiao, Y, Abraham, A, Yang, B, Croix, D, Redpath, S, Engstrom-Melnyk, J, Shah, RA, Madala, J, Allen, TC

April 2021

Manuscript

The Oncologist

Comparative effectiveness of first-line palbociclib plus letrozole versus letrozole alone for HR+/HER2−metastatic breast cancer in US real-world clinical practice

DeMichele, A, Cristofanilli, M, Brufsky, A, Liu, X, Mardekian, J, McRoy, L, Layman, RM, Emir, B, Torres, M, Rugo, HS, Finn, RS

March 2021

Manuscript

Breast Cancer Research

March 2021

Manuscript

Cancer

Flatiron-authored

Concurrent cetuximab and nivolumab as a second-line or beyond treatment of patients with recurrent and/or metastatic head and neck squamous cell carcinoma: results of phase I/II study

Chung, CH, Bonomi, M, Steuer, C, Li, J, Bhateja, P, Johnson, M, Masannat, J, Song, F, Hernandez-Prera, JC, Wenig, BM, Molena, H, Farinhas, JM, McMullen, CP, Wadsworth, JT, Patel, KB, Kish, JA, Muzaffar, J, Kirtane, K, Rocco, JW, Schell, MJ, Saba, NF

March 2021

Manuscript

Cancers

Characterization of a real-world response variable and comparison with RECIST-based response rates from clinical trials in advanced NSCLC

Ma, X, Bellomo, L, Magee, K, Bennette, CS, Tymejczyk, O, Samant, MK, Tucker, MG, Nussbaum, NC, Bowser, BE, Kraut, JS, Bourla, AB

March 2021

Manuscript

Advances in Therapy

Flatiron-authored

Real-world overall survival and time to therapy discontinuation of patients with mCRPC treated with second-generation novel hormonal therapies associated with tissue-based comprehensive genomic profiling

Graf, RP, Madison, RW, Gjoerup, O, Zhong, L, Morley, S, Chopra, S, Comment, L, Fisher, V, Li, G, MGregor, K, Schrock, AB, Tukachinsky, H, Snow, T, Cho-Phan, C, Swaminathan, A, Ross, JS, McCusker, M, Zurita, AJ, Venstrom, JM

February 2021

Abstract

ASCO GU Symposium

Flatiron-authored

Real-world clinical outcomes study of sequential novel antihormonal therapy or radium-223 treatment of metastatic castration-resistant prostate cancer that progressed after first-line NAH

Sartor, AO, George, DJ, Tombal, B, Higano, CS, Sternberg, CN, Miller, K, Jiao, X, Guo, H, Sandstrom, P, Verholen, F, Saad, F, Shore, ND

February 2021

Abstract

ASCO GU Symposium

February 2021

Abstract

ASCO GU Symposium

Real-world treatment patterns and sequencing for metastatic renal cell carcinoma: results from the Flatiron database

George, S, Faccone, J, Huo, S, Zhang, Y, Stwalley, B, Hamilton, M, Le, TK, Ejzykowicz, F

February 2021

Abstract

ASCO GU Symposium

February 2021

Abstract

ASCO GU Symposium

February 2021

Abstract

ASCO GU Symposium

February 2021

Abstract

ASCO GU Symposium

February 2021

Manuscript

European Journal of Haematology

February 2021

Manuscript

Advances in Therapy

February 2021

Manuscript

NPJ Digital Medicine

February 2021

Manuscript

Epidemiology

January 2021

Manuscript

Breast Cancer Research

RAS amplification as a negative predictor of benefit from anti-EGFR containing therapy regimens in metastatic colorectal cancer

Schrock, AB, Lee, JK, Sandhu, J, Madison, RW, Cho-Phan, C, Snider, JW, Castellanos, EH, Venstrom, JM, Fakih, M

January 2021

Manuscript

The Oncologist

Flatiron-authored

Real-world characterization of advanced non-small cell lung cancer in never smokers by actionable mutation status

Kerrigan, KC, Wang, X, Haaland, B, Adamson, BJS, Patel, SB, Puri, S, Akerley, WL

January 2021

Manuscript

Clinical Lung Cancer

Flatiron-authored

Association between post-treatment alpha-fetoprotein (AFP) reduction and outcomes in real-world US patients with advanced hepatocellular carcinoma

Gossai, A, Magee, K, Parrinello, CM, Miksad, RA, Kim, R, Abou-Alfa, G

January 2021

Abstract

ASCO GI Symposium

Flatiron-authored

January 2021

Manuscript

JCO Clinical Cancer Informatics

January 2021

Manuscript

JAMA Open

January 2021

Manuscript

BMC Cancer

December 2020

Abstract

HTAi

Flatiron-authored

December 2020

Manuscript

Current Medical Research and Opinion

December 2020

Abstract

American Society of Hematology Annual Meeting

December 2020

Abstract

American Society of Hematology Annual Meeting