Real-world evidence at ASCO21: Explore new research here

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Real-world outcomes of hormone receptor-positive (HR+) HER2-negative (HER2-) metastatic breast cancer (mBC) with high tumor mutational burden (hTMB) treated with immune checkpoint inhibitors (ICI)

Chumsri, S, Sammons, S, Alder, L, Sokol, ES, Danziger, NA, Raskina, K, Schrock, AB, Venstrom, JM, Snow, T, Castellanos, EH, Ochuonyo, E, Snider, JW, MGregor, K

September 2021

Abstract

ESMO Annual Congress

Flatiron-authored

ERBB2 copy number (CN) as a quantitative biomarker for real-world (RW) outcomes to anti-HER2 therapy in advanced gastroesophageal adenocarcinoma (adv GEA)

Klempner SJ, Zhang, L, Graf, RP, Madison, RW, Snider, JW, Cho-Phan, C, Castellanos, EH, Li, G, Nimeiri, H, Oxnard, G, Venstrom, JM, MGregor, K, Schrock, AB

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

Analysis of real world data (RWD) for metastatic breast cancer (mBC) patients (pts) without germline BRCA (gBRCA) alterations treated with PARP inhibitors (PARPi)

Tung, N, Madison, RW, Pavlick, D, Sokol, ES, Snow, T, Sondhi, A, Frampton, GM, Venstrom, JM, Castellanos, EH, Schrock, AB, MGregor, K

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

Plasma circulating tumor DNA (ctDNA) fraction and real-world overall survival (rwOS) in metastatic castration resistant prostate cancer (mCRPC)

Graf, RP, Li, G, Madison, RW, Schrock, AB, Huang, RSP, Oxnard, G, Venstrom, JM, Castellanos, EH, Snow, T, Swaminathan, A

June 2021

Abstract

ASCO Annual Meeting

Flatiron-authored

Patient with lobular carcinoma of the breast and activating AKT1 E17K variant

Trivedi, H, Hamdani, O, Thomas, B, Richard, J, Shah, K, Raskina, K, Zhang, L, Madigan, A, Fox, M, Wander, S, Frigault, M, Alexander, BM, Srkalovic, G

April 2021

Manuscript

Acta Medica Academia

TRK fusion cancer: patient characteristics and survival analysis in the real-world setting

Bazhenova, L, Lokker, A, Snider, JW, Castellanos, EH, Fisher, V, Fellous, M, Nanda, S, Zong, J, Keating, K, Jiao, X

April 2021

Manuscript

Targeted Oncology

Flatiron-authored

April 2021

Abstract

AACR Annual Meeting

Changes over time in real-world next-generation sequencing test use in patients with advanced non-small cell lung cancer

Swaminathan, A, Stergiopoulos, S, Snider, JW, Fisher, V, Castellanos, EH, Snow, T, Cho-Phan, C, Comment, L, Cunningham, R, McCusker, M

April 2021

Abstract

AACR Annual Meeting

Flatiron-authored

Comprehensive genomic profiling in breast cancer: patterns and results from a clinico-genomic database

Rody, A, Chaudhary, N, Craggs, C, Debiasi, M, Erb, G, Fisher, V, McCusker, M, Snow, T, Losada, MV, Luhn, P

April 2021

Abstract

AACR Annual Meeting

Flatiron-authored

Real-world overall survival and time to therapy discontinuation of patients with mCRPC treated with second-generation novel hormonal therapies associated with tissue-based comprehensive genomic profiling

Graf, RP, Madison, RW, Gjoerup, O, Zhong, L, Morley, S, Chopra, S, Comment, L, Fisher, V, Li, G, MGregor, K, Schrock, AB, Tukachinsky, H, Snow, T, Cho-Phan, C, Swaminathan, A, Ross, JS, McCusker, M, Zurita, AJ, Venstrom, JM

February 2021

Abstract

ASCO GU Symposium

Flatiron-authored

February 2021

Abstract

ASCO GU Symposium

February 2021

Manuscript

NPJ Digital Medicine

A platform to prospectively link real-world clinico-genomic, imaging, and outcomes data for patients with lung cancer

Walia, G, Lu, MW, Bourla, AB, Santos, EC, Schulze, K, Cabili, MN, Williams, EH, Mirkovich, N, DiCecca, RH, Lee, SE, Fang, B, Schwartzberg, L, Herbst, RS, Chiang, AC

January 2021

Abstract

World Conference on Lung Cancer

Flatiron-authored

STK11 (LKB1) mutations in metastatic NSCLC: prognostic value in the real world

Shire NJ, Klein, AB, Golozar, A, Collins, JM, Fraeman, KH, Nordstrom, BL, McEwen, R, Hembrough, T, Rizvi, NA

September 2020

Manuscript

PLoS One

Retrospective analysis of real-world data to determine clinical outcomes of patients with advanced non-small cell lung cancer following cell-free circulating tumor DNA genomic profiling

Madison, RW, Schrock, AB, Castellanos, EH, Gregg, JP, Snider, J, Ali, SM, Miller, VA, Singal, G, Alexander, BM, Venstrom, JM, Chung, JH

August 2020

Manuscript

Lung Cancer

Flatiron-authored

Identification of genomic alterations related to treatment progression in RWD

Chaudhary, N, Luhn, P, Jansen, G, Metcalfe, C, Hafner, M

May 2020

Abstract

AACR Annual Meeting

Characteristics and outcomes of real-world patients with microsatellite instability-high solid tumors treated with pembrolizumab monotherapy after FDA approval

Snow, T, Swaminathan, A, Snider, J, Schrock, AB, Li, G, Alexander, BM, Singal, G, Castellanos, EH, McCusker, M

May 2020

Abstract

ASCO Annual Meeting

Flatiron-authored

Association of BRCA alteration type with real-world outcomes to PARP inhibitors in patients with metastatic castrate-resistant prostate cancer

Antonarakis, ES, Madison, RW, Snider, J, Snow, T, Sokol, ES, Chung, JH, McCusker, M, Singal, G, Alexander, BM, Castellanos, EH, Venstrom, JM, Schrock, AB, Ross, JS

May 2020

Abstract

ASCO Annual Meeting

Flatiron-authored

A multi-stakeholder platform to prospectively link longitudinal real-world clinico-genomic, imaging, and outcomes data for patients with metastatic lung cancer

Lu, MW, Walia, G, Schulze, K, Doral, MY, Maund, SL, Gaffey, S, Cabili, MN, Bourla, AB, Green, RJ, Santos, EC, Herbst, RS, Chiang, AC, Schwartzberg, L

May 2020

Abstract

ASCO Annual Meeting

Flatiron-authored

Real-world outcomes for advanced non-small cell lung cancer patients with EGFR exon 19 deletions stratified by deletion size

Ou, SI, Madison, RW, Snow, T, Snider, J, McCusker, M, Singal, G, Alexander, BM, Venstrom, JM, Castellanos, EH, Schrock, AB

May 2020

Abstract

ASCO Annual Meeting

Flatiron-authored

April 2020

Manuscript

Cancer Discovery

Flatiron-authored

Association of real-world agreement between HER2 expression and ERBB2 amplification with trastuzumab therapy benefit in advanced gastric/esophageal (adv GE) cancer patients (pts)

Stein, S, Snider, J, McCusker, M, Miksad, RA, Alexander, BM, Castellanos, EH, Backenroth, D, Schrock, AB, Madison, R, Carson, KR, Ali, SM

January 2020

Abstract

ASCO GI Symposium

Flatiron-authored

Cancers with NTRK gene fusions: molecular characteristics and prognosis

Bazhenova, L, Jiao, X, Lokker, A, Snider, J, Castellanos, EH, Nanda, S, Fisher, V, Zong, J, Keating ,K, Fellous, M

January 2020

Abstract

AACR Special Meeting

Flatiron-authored

January 2020

Abstract

AACR Special Meeting

December 2019

Abstract

San Antonio Breast Cancer Symposium

Co-occurrence of NTRK fusions with other genomic biomarkers in cancer patients

Jiao, X, Lokker, A, Snider, J, Castellanos, EH, Nanda, S, Fisher, V, Zong, J, Keating, K, Fellous, M

September 2019

Abstract

ESMO Annual Congress

Flatiron-authored

Prevalence and prognostic effect of high tumor mutation burden (TMB-H) across multiple less common solid cancers using a real-world dataset

Backenroth D, Shao C, Li G, Huang L,Pruitt SK, Castellanos EH, Frampton GM, Carson KR, Snow T, Singal G, Fabrizio D, Alexander BM, Jin FJ, Zhou W

September 2019

Abstract

ESMO Annual Congress

Flatiron-authored

BRAF mutations are associated with increased benefit from PD-1/PD-L1 blockade compared with other oncogenic drivers in non-small cell lung cancer

Heymach, JV, Shames, DS, Albacker, LA, Frampton, GM, Alexander, BM, Miller, VA, Glisson, BS, Gibbons, DL, Papadimitrakopoulou, V, Tsao, AS, Lee, J, Swisher, S, Roth, JA, Simon, GS, Rinsurongkawong, W, Barreto, D, Zhang, J, Wu, C-J, Goldberg, ME, Le, X, Elamin, Y, Hu, S, Shen, V, Bara, I, Schulze, K, Montesion, M, Skoulidis, F, Negrão, M

September 2019

Abstract

World Conference on Lung Cancer

Retrospective analysis of real-world clinico-genomic data for clinical impact of genomic profiling of CTDNA in NSCLC

Madison, R, Schrock, AB, Gregg, JP, Carson, KR, Castellanos, EH, Singal, G, Miller, VA, Ali, SM, Alexander, BM, Chung, JH

September 2019

Abstract

World Conference on Lung Cancer

Flatiron-authored

Tumor mutational burden and PD-L1 expression as predictors of response to immunotherapy in NSCLC

Castellanos E, Snider J, Ali SM, Backenroth D, Albacker LA, Murugesan K, Li G, Frampton GM, Alexander BM, Carson KR

June 2019

Abstract

ASCO Annual Meeting

Flatiron-authored

Genomic characterization of lung tumors and metastatic sites in advanced NSCLC

Willard MD, Smyth EN, Tiu RV, Beyrer J, Zhu YE, Bowman L, Sheffield KM, Han Y, Brastianos P

June 2019

Abstract

ASCO Annual Meeting

Clinical characteristics, treatment patterns, and overall survival in advanced NSCLC patients with and without brain metastases

Smyth EN, Tiu RV, Willard MD, Beyrer J, Zhu YE, Bowman L, Sheffield KM, Han Y, Brastianos P

June 2019

Abstract

ASCO Annual Meeting

June 2019

Abstract

ASCO Annual Meeting

February 2019

Abstract

ASCO GU Symposium

October 2018

Abstract

ESMO Annual Congress

Distinctive Clinical Characteristics of SCLC in Never-Smokers

Mian I, Nichols S, Abernethy AP, Carson K, Maignan K, Torres AZ, Snider J, Frampton G, Li G, Sharon E, Szabo E, Thomas A

September 2018

Abstract

World Conference on Lung Cancer

Flatiron-authored

June 2018

Abstract

ASCO Annual Meeting

June 2018

Abstract

ASCO Annual Meeting

Identifying the Prognostic Significance of Genomic Alterations in a Real-World, EHR-Derived Clinico-Genomic Database (CGDB)

Agarwala V, Backenroth D, Singal G, O'Connell C, Li G, Alpha-Cobb G, Kaushik G, Carson K, Miller V, Abernethy AP

June 2018

Abstract

ASCO Annual Meeting

Flatiron-authored

Prevalence of Microsatellite Instability and Association with Pembrolizumab (P) Usage in a Real-World Clinico-Genomic Database

O'Connell C, Backenroth D, Singal G, Agarwala V, Li G, Kaushik G, Alpha-Cobb G, Kao CK, Miller V, Abernethy AP, Carson K

June 2018

Abstract

ASCO Annual Meeting

Flatiron-authored

Real-World Evidence In Support Of Precision Medicine: Clinico-Genomic Cancer Data As A Case Study

Agarwala V, Khozin S, Singal G, O'Connell C, Kuk D, Li G, Gossai A, Miller V, Abernethy AP

May 2018

Manuscript

Health Affairs

Flatiron-authored

Identification of Resistance Mechanisms to EGFR Treatment in the Real World Using a Clinicogenomic Database

Singal G, Agarwal A, Kaushik G, O'Connell C, Alpha-Cobb G, Caron T, Bourque D, Guria A, Frank S, Frampton G, Carson K, Abernethy AP, Miller V

April 2018

Abstract

American Association for Cancer Research Annual Meeting

Flatiron-authored

Analyzing Biomarkers of Cancer Immunotherapy (CIT) Response Using a Real-World Clinico-Genomic Database

Singal G, Miller P, Agarwala V, Li G, Gossai A, Albacker L, Goldberg M, He J, Frank S, Bourque D, Ivanov V, Fabrizio D, Caron T, Parker A, Guria A, Miller V, Elvin J, Ross J, Abernethy AP, Stephens P

September 2017

Abstract

ESMO Annual Congress

Flatiron-authored

Development and Validation of a Real-World Clinico-Genomic Database

Singal G, Miller P, Agarwala V, He J, Gossai A, Frank S, Bourque D, Bowser B, Caron T, Baydur E, Seidl-Rathkopf K, Ivanov I, Parker A, Guria A, Frampton G, Jaskiw A, Feuchtbaum D, Nussbaum N, Abernethy AP, Miller V

June 2017

Abstract

ASCO Annual Meeting

Flatiron-authored