Flatiron Health Announces Research to be Presented at American Society of Clinical Oncology 2021 Annual Meeting

May 21, 2021


Flatiron Health today announced eight abstracts have been accepted for presentation at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, to be held June 4-8.

“Flatiron’s research continues to demonstrate the important applications of real-world data and the insights of real-world evidence,” said Michael Vasconcelles, MD, Chief Medical Officer at Flatiron. “The research abstracts being presented at ASCO 2021 include work illuminating racial disparities in treatment among breast cancer patients, advancing our understanding of the COVID-19 pandemic’s impact on cancer treatment, and matching patients to clinical trials through an AI-based point-of-care tool.”  

This year’s accepted abstracts again reflect Flatiron’s many collaborations and partnerships in pursuit of its mission to improve lives by learning from the experience of every cancer patient. 

Highlights include:

  • an investigation of racial disparities in treatment patterns among breast cancer patients, aligned with the 2021 ASCO theme of “Equity: Every Patient. Every Day. Everywhere.” 
  • a machine-learning tool that can ultimately improve patients’ access to clinical trials by improving the efficiency of patient ascertainment and thereby removing a barrier for practices to take part in studies of rare populations
  • a deep learning algorithm that automates the extraction of dates of key clinical events from unstructured chart notes, reducing the need for human curation in real-world data (RWD) research
  • leveraging the Flatiron Health-Foundation Medicine Clinico-Genomic Database to understand implications of NGS-defined biomarkers in patients with breast cancer and gastroesophageal cancers 
  • an illustration of the power of a nationwide RWD network in aggregating clinical information to study treatment patterns and outcomes in patients with Castleman disease, a rare lymphoproliferative disorder
  • a description of the evolving impact of the COVID-19 pandemic on cancer treatment. 

Flatiron collaborated on the accepted research with: Beth Israel Deaconess Medical Center, Birmingham Hematology Oncology (Alabama Oncology), Cancer Partners of Nebraska, Dana-Farber Cancer Institute, Foundation MedicineFox Chase Cancer CenterMassachusetts General HospitalMoffitt Cancer CenterPenn MedicineUniversity of Alabama at Birmingham and Yale University.

Full abstracts will be posted at rwe.flatiron.com post-ASCO embargo on June 4. 


Poster Presentations


Analysis of real-world (RW) data for metastatic breast cancer (mBC) patients (pts) with somatic BRCA1/2 (sBRCA) or other homologous recombination (HR)-pathway gene mutations (muts) treated with PARP inhibitors (PARPi)

First author: Felipe Batalini (Beth Israel Deaconess Medical Center)

Abstract: 10512


Clinical characteristics, treatment patterns, and overall survival of real-world patients with idiopathic multicentric Castleman disease

First author: Aaron B. Cohen (Flatiron Health)

Abstract: 7048


Concordance of HER2+ status by IHC/ISH and ERBB2 status by NGS in a real-world clinicogenomic database and analysis of outcomes in patients (pts) with metastatic breast cancer (mBC)

First author: Cheryl D. Cho-Phan (Flatiron Health)

Abstract: 1036


ERBB2 copy number (CN) as a quantitative biomarker for real-world (RW) outcomes to anti-HER2 therapy in advanced gastroesophageal adenocarcinoma (adv GEA)

First author: Samuel J. Klempner (Massachusetts General Hospital)

Abstract: 4045


Extracting non-small cell lung cancer (NSCLC) diagnosis and diagnosis dates from electronic health record (EHR) text using a deep learning algorithm

First author: Alexander S. Rich (Flatiron Health)

Abstract: 1556


Racial disparities in second-line (2L) treatment and overall survival among patients (pts) with hormone receptor positive HER2 negative (HR+HER2-) metastatic breast cancer (mBC) treated in routine practice

First author: Xiaoliang Wang (Flatiron Health)

Abstract: 6541


Impact of COVID-19 pandemic on time to treatment initiation for patients with advanced cancer

First author: Samuel U. Takvorian (Perelman School of Medicine at the University of Pennsylvania)

Abstract: 1528


An automated EHR-based tool to facilitate patient identification for biomarker-driven trials

First author: Shailendra Lakhanpal (Birmingham Hematology Oncology/Alabama Oncology) 

Abstract: 1539

About Flatiron
Flatiron Health is a healthtech company expanding the possibilities for point of care solutions in oncology and using data for good to power smarter care for every person with cancer. Through machine learning and AI, real-world evidence, and breakthroughs in clinical trials, we continue to transform patients’ real-life experiences into knowledge and create a more modern, connected oncology ecosystem. Flatiron Health is an independent affiliate of the Roche Group. Flatiron.com @FlatironHealth

Media Contact: Nina Toor