Advancing the use of RWE with our research collaborators
Flatiron RWD has been used in projects across the drug development life cycle
Discovery & early development
Our RWD demonstrated that STK11 and KEAP1 mutations are negatively associated with real-world outcomes in both chemotherapy and PD-1/PD-L1 checkpoint inhibitors-treated NSCLC patients.
Our RWD can help inform the design of randomized controlled trials, such as by informing the selection of inclusion/exclusion criteria.
To inform regulatory decision making, RWD needs to be fit-for-purpose and tailored to specific regulatory and clinical contexts. Our RWD has provided supportive evidence to inform regulatory decision making.
Our RWD was used to help assess the safety of a drug in breast cancer patients with a certain type of heart failure, leading to a favorable label update in Europe and the U.S.
HTA bodies around the world assessed our RWD to characterize the natural history of a disease as part of reimbursement evaluations for novel therapies.
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More than 20 of the world’s top biopharma companies use Flatiron real-world data products to support their R&D pipelines and enhance their understanding of real-world cancer care.
Add-ons to our products:
Real-world outcome variables
Flatiron’s real-world outcome variables, used to derive real-world endpoints, account for the inherent complexities of patient outcomes specific to each cancer type.